Biocompatibility Testing

For a substance to be biocompatible, it must have qualities that enable it to exist within a living organism without causing harm. This term is relevant to dentistry because there are various materials used to repair and restore teeth. As we have learned with dental amalgam, which contains mercury, not all dental materials are as safe as some would have us believe. When you consider that you will have your new dental restorations in your mouth 24/7, this issue becomes very important.

The biocompatibility of a dental material comes from its ability to carry out the function for which it is intended without resulting in undesirable effects, either in the mouth or the body. Through this testing, we look for the lack of allergic, inflammatory, or toxic response in tissues surrounding the restoration. There should also be no negative impact on general health.

We do not believe in a “wait and see” approach when it comes to biocompatibility. In our Austin dental practice, we offer convenient biocompatibility testing that will provide us with detailed information necessary to provide each patient with truly customized care.

Dr. Cole does serum biocompatibility testing using Clifford Consulting and Research laboratories, located in Colorado Springs. This reputable immunology lab receives blood samples from our patients, which are drawn at a nearby medical office, and performs a comprehensive testing process that screens for sensitivities to biomaterials via detection of antibodies. Through this testing process, Dr. Cole is provided with a detailed list of the various dental materials that can safely be used in a patient’s treatment process.

The MELISA test, which also analyzes blood serum, is another way in which compatibility can be assessed. This test detects “delayed hypersensitivity” to metals such as titanium and gold, among others.

For those very discerning patients who like their practitioner to perform physiological testing, Dr. Cole will be happy to provide all the necessary materials.

Our approach to dentistry is to provide the highest level of care that will promote excellent oral and general health. Through biocompatibility testing, we can ensure that each patient is receiving the precise care that he or she requires.

Contact our office to learn more about us, or to schedule your personal consultation.

E. Griffin Cole, DDS, NMD Best dental office near Austin, TX

E. Griffin Cole, DDS, NMD - Advanced Biologic Restorative Dentistry
Biocompatible Focus - Integrative Approach

Biological dental care at its finest is the promise made by the team at the office of E. Griffin Cole, DDS, NMD. We are dedicated to helping you achieve your best oral health and general well-being through comprehensive integrative dental care.

Dr. Griffin Cole earned his dental degree from the University of Texas Health Science Center, San Antonio Dental School. He has three decades of experience in dentistry and is trusted by Austin, TX residents. He was the first dentist in Texas to have a mercury-separating system in his office, and the first dentist in Austin to be certified in oxygen-ozone therapy. He’s a member of many reputed dental associations including the IAOMT, and teaches practice management and growth at the American College of Integrative Medicine and Dentistry. Dr. Cole is a published author and follows continuing education programs on a regular basis. Connect with Dr. Griffin Cole on Linkedin.


Dr Griffin Cole has been awarded with Austin Premier Doctor Award 2019

Dr Griffin Cole has been awarded with Austin Premier Doctor Award 2019

Karen S.
I've been a patient with Dr. Cole for over 10 years. If you want the best dentist in town, someone who knows about natural health but also embraces cutting edge technology and research, go to Dr. Cole. On top of that, he is accesible and truly cares about every patient. I'm so glad I found him. You cannot find better both for cosmetic dentistry and general health. Read More